Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases
Identifieur interne : 002819 ( Main/Exploration ); précédent : 002818; suivant : 002820Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases
Auteurs : Ross A. Clevens [États-Unis] ; M. Flint Beal [États-Unis]Source :
- Brain Research [ 0006-8993 ] ; 1989.
English descriptors
- KwdEn :
Abstract
Substance P is found in both the basal ganglia and cerebral cortex in mammalian brain. In the present study postmortem concentrations of substance P-like immunoreactivity (SP-LI) were measured in the globus pallidus, substantia nigra and 22 cortical regions in a group of demented patients with neuropathological features of both Parkinson's disease (PD) and Alzheimer's disease (AD), and from neurologically normal controls. There were no significant changes in the globus pallidus but concentrations were significantly reduced by 44% in the substantia nigra compacta in the PD patients. In cerebral cortex small (20–30%) significant reductions of SP-LI were found in the PD patients in 7 of 22 cortical regions examined. These results are similar to changes found in AD alone and provide further evidence that the dementia of PD is frequently related to the coicidence of PD and AD.
Url:
DOI: 10.1016/0006-8993(89)90529-5
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases</title><author><name sortKey="Clevens, Ross A" sort="Clevens, Ross A" uniqKey="Clevens R" first="Ross A." last="Clevens">Ross A. Clevens</name></author><author><name sortKey="Beal, M Flint" sort="Beal, M Flint" uniqKey="Beal M" first="M. Flint" last="Beal">M. Flint Beal</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7C0107C4C0CD8CFAB56A2410DA705F1A2C4E0E86</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1016/0006-8993(89)90529-5</idno><idno type="url">https://api.istex.fr/document/7C0107C4C0CD8CFAB56A2410DA705F1A2C4E0E86/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002629</idno><idno type="wicri:Area/Main/Curation">002289</idno><idno type="wicri:Area/Main/Exploration">002819</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases</title><author><name sortKey="Clevens, Ross A" sort="Clevens, Ross A" uniqKey="Clevens R" first="Ross A." last="Clevens">Ross A. Clevens</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Beal, M Flint" sort="Beal, M Flint" uniqKey="Beal M" first="M. Flint" last="Beal">M. Flint Beal</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">486</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="387">387</biblScope><biblScope unit="page" to="390">390</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">7C0107C4C0CD8CFAB56A2410DA705F1A2C4E0E86</idno><idno type="DOI">10.1016/0006-8993(89)90529-5</idno><idno type="PII">0006-8993(89)90529-5</idno><idno type="ArticleID">89905295</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>Neuropeptide</term><term>Tachykinin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Substance P is found in both the basal ganglia and cerebral cortex in mammalian brain. In the present study postmortem concentrations of substance P-like immunoreactivity (SP-LI) were measured in the globus pallidus, substantia nigra and 22 cortical regions in a group of demented patients with neuropathological features of both Parkinson's disease (PD) and Alzheimer's disease (AD), and from neurologically normal controls. There were no significant changes in the globus pallidus but concentrations were significantly reduced by 44% in the substantia nigra compacta in the PD patients. In cerebral cortex small (20–30%) significant reductions of SP-LI were found in the PD patients in 7 of 22 cortical regions examined. These results are similar to changes found in AD alone and provide further evidence that the dementia of PD is frequently related to the coicidence of PD and AD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Clevens, Ross A" sort="Clevens, Ross A" uniqKey="Clevens R" first="Ross A." last="Clevens">Ross A. Clevens</name></region><name sortKey="Beal, M Flint" sort="Beal, M Flint" uniqKey="Beal M" first="M. Flint" last="Beal">M. Flint Beal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002819 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002819 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:7C0107C4C0CD8CFAB56A2410DA705F1A2C4E0E86
|texte= Substance P-like immunoreactivity in brains with pathological features of Parkinson's and Alzheimer's diseases
}}
| This area was generated with Dilib version V0.6.23. |  |